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Article

AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans.

Current biology : CB - 6 Feb 2007

Quevedo Celia, Kaplan David R, Derry W Brent

Abstract excerpt

The cellular response to genotoxic stress involves the integration of multiple prosurvival and proapoptotic signals that dictate whether a cell lives or dies. In mammals, AKT/PKB regulates cell survival by modulating the activity of several apoptotic proteins, including p53. In Caenorhabditis elegans, akt-1 and akt-2 regulate development in response to environmental cues by controlling the FOXO transcription...

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Identifiers

PMID: 17276923
DOI: 10.1016/j.cub.2006.12.038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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