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Article

WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane.

PloS one - 1 Jan 2014

Vilardi Fabio, Stephan Milena, Clancy Anne, Janshoff Andreas, Schwappach Blanche

Abstract excerpt

Tail-Anchored (TA) proteins are inserted into the endoplasmic reticulum (ER) membrane of yeast cells via the posttranslational Guided Entry of Tail-Anchored protein (GET) pathway. The key component of this targeting machinery is the ATPase Get3 that docks to the ER membrane by interacting with a receptor complex formed by the proteins Get1 and Get2. A conserved pathway is present in higher eukaryotes and is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24392163
DOI: 10.1371/journal.pone.0085033
PMCID: PMC3879356

Genes

GET1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane.PMID 24392163Read ↗

Endoplasmic reticulum membrane receptors of the GET pathway are conserved throughout eukaryotes.Semantic proximity Read ↗

The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase.Semantic proximity Read ↗

Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells.Semantic proximity Read ↗

Subunit cooperation in the Get1/2 receptor promotes tail-anchored membrane protein insertion.Semantic proximity Read ↗

A chaperone cascade sorts proteins for posttranslational membrane insertion into the endoplasmic reticulum.Semantic proximity Read ↗

The conserved ATPase Get3/Arr4 modulates the activity of membrane-associated proteins in Saccharomyces cerevisiae.Semantic proximity Read ↗

Crystal structure of bet3 reveals a novel mechanism for Golgi localization of tethering factor TRAPP.Semantic proximity Read ↗

Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast.Semantic proximity Read ↗

Model for eukaryotic tail-anchored protein binding based on the structure of Get3.Semantic proximity Read ↗

Characterization of the yeast tricalbins: membrane-bound multi-C2-domain proteins that form complexes involved in membrane trafficking.Semantic proximity Read ↗

Structural characterization of the Get4/Get5 complex and its interaction with Get3.Semantic proximity Read ↗

The GET System Inserts the Tail-Anchored Protein, SYP72, into Endoplasmic Reticulum Membranes.Semantic proximity Read ↗

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