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Article

<scp>DNA</scp> methylation and expression of <i><scp>KCNQ</scp>3</i> in bipolar disorder

11 Jul 2014

Abstract excerpt

OBJECTIVES: Accumulating evidence implicates the potassium voltage-gated channel, KQT-like subfamily, member 2 and 3 (KCNQ2 and KCNQ3) genes in the etiology of bipolar disorder (BPD). Reduced KCNQ2 or KCNQ3 gene expression might lead to a loss of inhibitory M-current and an increase in neuronal hyperexcitability in disease. The goal of the present study was to evaluate epigenetic and gene expression associations...

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PMID: 25041603
DOI: 10.1111/bdi.12230

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