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Article

The role of DNA methylation in the pathophysiology and treatment of bipolar disorder.

Neuroscience and biobehavioral reviews - 1 Sept 2016

Fries Gabriel R, Li Qiongzhen, McAlpin Blake, Rein Theo, Walss-Bass Consuelo, Soares Jair C, Quevedo Joao

Abstract excerpt

Bipolar disorder (BD) is a multifactorial illness thought to result from an interaction between genetic susceptibility and environmental stimuli. Epigenetic mechanisms, including DNA methylation, can modulate gene expression in response to the environment, and therefore might account for part of the heritability reported for BD. This paper aims to review evidence of the potential role of DNA methylation in the...

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Identifiers

PMID: 27328785
DOI: 10.1016/j.neubiorev.2016.06.010
PMCID: PMC5003658

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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