Article
Cis-acting regulation of brain-specific ANK3 gene expression by a genetic variant associated with bipolar disorder.
Molecular psychiatry - 1 Aug 2013
Rueckert E H, Barker D, Ruderfer D, Bergen S E, O'Dushlaine C, Luce C J, Sheridan S D, Theriault K M, Chambert K, Moran J, Purcell S M, Madison J M, Haggarty S J, Sklar P
Abstract excerpt
Several genome-wide association studies for bipolar disorder (BD) have found a strong association of the Ankyrin 3 (ANK3) gene. This association spans numerous linked single-nucleotide polymorphisms (SNPs) in an ~250-kb genomic region overlapping ANK3. The associated region encompasses predicted regulatory elements as well as two of the six validated alternative first exons, which encode distinct protein domains...
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