Mapping the expression of an ANK3 isoform associated with bipolar disorder in the human brain.

doi:10.1038/s41398-022-01784-6

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Article

Mapping the expression of an ANK3 isoform associated with bipolar disorder in the human brain.

Translational psychiatry - 28 Jan 2022

Holmgren Asbjørn, Hansson Lars, Bjerkaas-Kjeldal Kristine, Impellizzeri Agata Antonia Rita, Gilfillan Gregor D, Djurovic Srdjan, Hughes Timothy

Abstract excerpt

The gene ankyrin-3 (ANK3) has been consistently associated with bipolar disorder (BD) in several genome-wide association studies (GWAS). The exact molecular mechanisms underlying this genetic association remain unknown. The discovery of a loss-of-function variant (rs41283526*G) in an alternatively spliced exon (ENSE00001786716) with a protective effect, suggested that elevated expression of this particular...

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Identifiers

PMID: 35091539
DOI: 10.1038/s41398-022-01784-6
PMCID: PMC8799726

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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