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Article

Pathway analysis using information from allele-specific gene methylation in genome-wide association studies for bipolar disorder.

PloS one - 1 Jan 2013

Chuang Li-Chung, Kao Chung-Feng, Shih Wei-Liang, Kuo Po-Hsiu

Abstract excerpt

Bipolar disorder (BPD) is a complex psychiatric trait with high heritability. Despite efforts through conducting genome-wide association (GWA) studies, the success of identifying susceptibility loci for BPD has been limited, which is partially attributed to the complex nature of its pathogenesis. Pathway-based analytic strategy is a powerful tool to explore joint effects of gene sets within specific biological...

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PMID: 23326387
DOI: 10.1371/journal.pone.0053092
PMCID: PMC3541404

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