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Article

CACNA1C hypermethylation is associated with bipolar disorder.

Translational psychiatry - 7 Jun 2016

Starnawska A, Demontis D, Pen A, Hedemand A, Nielsen A L, Staunstrup N H, Grove J, Als T D, Jarram A, O'Brien N L, Mors O, McQuillin A, Børglum A D, Nyegaard M

Abstract excerpt

The CACNA1C gene, encoding a subunit of the L-type voltage-gated calcium channel is one of the best-supported susceptibility genes for bipolar disorder (BD). Genome-wide association studies have identified a cluster of non-coding single-nucleotide polymorphisms (SNPs) in intron 3 to be highly associated with BD and schizophrenia. The mechanism by which these SNPs confer risk of BD appears to be through an altered...

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PMID: 27271857
DOI: 10.1038/tp.2016.99
PMCID: PMC4931616

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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