Article
A Loss-of-Function Variant in a Minor Isoform of ANK3 Protects Against Bipolar Disorder and Schizophrenia.
Biological psychiatry - 15 Aug 2016
Hughes Timothy, Hansson Lars, Sønderby Ida E, Athanasiu Lavinia, Zuber Verena, Tesli Martin, Song Jie, Hultman Christina M, Bergen Sarah E, Landén Mikael, Melle Ingrid, Andreassen Ole Andreas, Djurovic Srdjan
Abstract excerpt
BACKGROUND: Ankyrin-3 (ANK3) was one of the first genes to reach significance in a bipolar disorder genome-wide association study. Many subsequent association studies confirmed this finding and implicated this gene in schizophrenia. However, the exact nature of the role of ANK3 in the pathophysiology remains elusive. In particular, the specific isoforms involved and the nature of the imbalance are unknown....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.