Article
Further evidence for association of GRK3 to bipolar disorder suggests a second disease mutation.
Psychiatric genetics - 1 Dec 2007
Barrett Thomas B, Emberton John E, Nievergelt Caroline M, Liang Sherri G, Hauger Richard L, Eskin Eleazar, Schork Nicholas J, Kelsoe John R
Abstract excerpt
OBJECTIVES: Two genome-wide linkage surveys suggest chromosome 22q12 may contain a susceptibility locus for bipolar disorder (BPD) in the immediate region of the gene G protein receptor kinase-3 (GRK3). We previously published evidence that a single nucleotide polymorphism (SNP) in the promoter region of GRK3, designated P5, was associated with BPD. This SNP, however, was too rare (allele frequency 0.007) to...
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