Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Revisiting TP53 Mutations and Immunohistochemistry--A Comparative Study in 157 Diffuse Gliomas.

Brain pathology (Zurich, Switzerland) - 1 May 2015

Takami Hirokazu, Yoshida Akihiko, Fukushima Shintaro, Arita Hideyuki, Matsushita Yuko, Nakamura Taishi, Ohno Makoto, Miyakita Yasuji, Shibui Soichiro, Narita Yoshitaka, Ichimura Koichi

Abstract excerpt

The association between p53 immunohistochemistry and TP53 mutation status has been controversial. The present study aims to re-evaluate the efficacy of p53 immunohistochemistry to predict the mutational status of TP53. A total of 157 diffuse gliomas (World Health Organization grades II-IV) were assessed by exon-by-exon DNA sequencing from exon 4 through 10 of TP53 using frozen tissue samples. Immunohistochemistry...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glioma

Share to Immunohistochemistry

Share to ROC Curve

Share to Statistics as Topic

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 25040820
DOI: 10.1111/bpa.12173
PMCID: PMC8028857

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Revisiting TP53 Mutations and Immunohistochemistry--A Comparative Study in 157 Diffuse Gliomas.PMID 25040820Read ↗

TP53 and p53 statuses and their clinical impact in diffuse low grade gliomas.Semantic proximity Read ↗

The predictive capability of immunohistochemistry and DNA sequencing for determining TP53 functional mutation status: a comparative study of 41 glioblastoma patientsSemantic proximity Read ↗

A Retrospective Study of the Correlation Between Next-Generation Sequencing and Immunohistochemical Detection of TP53 in Colorectal Cancer.Semantic proximity Read ↗

Correlating p53 immunostaining patterns with somatic TP53 mutation and functional properties of mutant p53 in triple-negative breast cancerSemantic proximity Read ↗

Prediction of TP53 mutations by p53 immunohistochemistry and their prognostic significance in gastric cancerSemantic proximity Read ↗

p53 mutation and protein alteration in 50 gliomas. Retrospective study by DNA-sequencing techniques and immunohistochemistry.Semantic proximity Read ↗

Detection of TP53 mutations by immunohistochemistry in acute myeloid leukemia varies with interpreter expertise and mutation status.Semantic proximity Read ↗

p53 immunostaining pattern is a useful surrogate marker for TP53 gene mutations.Semantic proximity Read ↗

Redefining aberrant P53 expression of gastric cancer and its distinct clinical significance among molecular-histologic subtypes.Semantic proximity Read ↗

Clinical significance of p53 protein expression and TP53 variation status in colorectal cancer.Semantic proximity Read ↗

High-resolution melting effectively pre-screens for TP53 mutations before direct sequencing in patients with diffuse glioma.Semantic proximity Read ↗

Immunohistochemical correlates of TP53 somatic mutations in cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.