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Article

p53 immunostaining pattern is a useful surrogate marker for TP53 gene mutations.

Diagnostic pathology - 5 Dec 2022

Sung You-Na, Kim Deokhoon, Kim Jihun

Abstract excerpt

BACKGROUND: TP53 is the most frequently mutated gene in the human cancer, and the awareness of its mutational status is useful in the diagnosis and treatment of cancer patients. In the present study, we investigated the association between TP53 gene mutations and p53 immunohistochemical staining (IHC) patterns and non-genetic effect of MDM2 as a negative regulator of p53. METHODS: A total of 135 solid cancer...

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Identifiers

PMID: 36471402
DOI: 10.1186/s13000-022-01273-w
PMCID: PMC9720942

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