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Article

A Retrospective Study of the Correlation Between Next-Generation Sequencing and Immunohistochemical Detection of TP53 in Colorectal Cancer.

Technology in cancer research & treatment - 1 Jan 2026

Wu Jingjing, Yu Haifeng, Huang Shanshan, Chen Xiangna

Abstract excerpt

IntroductionThis retrospective study aimed to investigate the correlation between TP53 identified via next-generation sequencing (NGS) and p53 expression in colorectal adenocarcinoma (CRC), as assessed by immunohistochemistry (IHC). Additionally, we characterized p53 IHC staining patterns and sought to determine the optimal threshold for p53 expression as a surrogate for TP53 mutation status.MethodsIn this...

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Identifiers

PMID: 41615842
DOI: 10.1177/15330338261420099
PMCID: PMC12858738

Genes

TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 15 Oct 2026.

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