Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High-resolution melting effectively pre-screens for TP53 mutations before direct sequencing in patients with diffuse glioma.

Human cell - 1 Mar 2021

Saito Kiyotaka, Yokogami Kiyotaka, Maekawa Kazunari, Sato Yuichiro, Yamashita Shinji, Matsumoto Fumitaka, Mizuguchi Asako, Takeshima Hideo

Abstract excerpt

TP53 mutations are important molecular markers in diffuse astrocytic tumors and medulloblastomas. We examined the efficacy of a pre-screening method for high-resolution melting (HRM) analysis of TP53 mutation before direct sequencing using samples from patients with diffuse glioma. Surgical samples from 64 diffuse gliomas were classified based on the 2016 World Health Organization (WHO) histopathological grading...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytoma
Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dermatitis, Allergic Contact

Share to Genetic Testing

Share to Glioblastoma

Share to Immunohistochemistry

Share to Mutation, Missense

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 33454902
DOI: 10.1007/s13577-020-00471-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High-resolution melting effectively pre-screens for TP53 mutations before direct sequencing in patients with diffuse glioma.PMID 33454902Read ↗

Detection of IDH1 and IDH2 mutations by fluorescence melting curve analysis as a diagnostic tool for brain biopsies.Semantic proximity Read ↗

Molecular diagnosis of diffuse glioma using a chip-based digital PCR system to analyze IDH, TERT, and H3 mutations in the cerebrospinal fluid.Semantic proximity Read ↗

Evaluation of High-Resolution Melting Analysis as a Diagnostic Tool to Detect the BRAF V600E Mutation in Colorectal TumorsSemantic proximity Read ↗

Comparison of high-resolution melting analysis with direct sequencing for the detection of recurrent mutations in DNA methyltransferase 3A and isocitrate dehydrogenase 1 and 2 genes in acute myeloid leukemia patients.Semantic proximity Read ↗

Detection of somatic mutations by high-resolution DNA melting (HRM) analysis in multiple cancers.Semantic proximity Read ↗

DNA methylation analysis with methylation‐sensitive high‐resolution melting (MS‐HRM) reveals gene panel for glioma characteristicsSemantic proximity Read ↗

TP53 and p53 statuses and their clinical impact in diffuse low grade gliomas.Semantic proximity Read ↗

COLD PCR HRM: a highly sensitive detection method for IDH1 mutations.Semantic proximity Read ↗

High-throughput amplicon scanning of the TP53 gene in breast cancer using high-resolution fluorescent melting curve analyses and automatic mutation calling.Semantic proximity Read ↗

Evaluation of the melting temperature of TaqMan probes as a genotyping method for IDH1, IDH2, and H3F3A in pediatric astrocytomas.Semantic proximity Read ↗

Method for the Intraoperative Detection of IDH Mutation in Gliomas with Differential Mobility Spectrometry.Semantic proximity Read ↗

High-resolution melting analysis for accurate detection of BRAF mutations: a systematic review and meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.