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Histone chaperone ASF1A is required for maintenance of pluripotency and cellular reprogramming

18 Jul 2014

Abstract excerpt

Unfertilized oocytes have the intrinsic capacity to remodel sperm and the nuclei of somatic cells. The discoveries that cells can change their phenotype from differentiated to embryonic state using oocytes or specific transcription factors have been recognized as two major breakthroughs in the biomedical field. Here, we show that ASF1A, a histone-remodeling chaperone specifically enriched in the metaphase II...

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PMID: 25035411
DOI: 10.1126/science.1254745

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