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Article

Enucleated Ovine Oocyte Supports Human Somatic Cells Reprogramming Back to the Embryonic Stage

1 Apr 2012

Abstract excerpt

Increased possibility of universality of ooplasmic reprogramming factors resulted in a parallel increased interest to use interspecies somatic cell nuclear transfer (iSCNT) to address basic questions of developmental biology and to improve the feasibility of cell therapy. In this study, the interactions between human somatic cells and ovine oocytes were investigated. Nuclear remodeling events were first observed...

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PMID: 22384929
DOI: 10.1089/cell.2011.0061

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