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Article

Evaluation in mammalian oocytes of gene transcripts linked to epigenetic reprogramming

21 Sept 2007

Abstract excerpt

The mature mammalian metaphase II (MII) oocyte has a unique ability to reprogram sperm chromatin and support early embryonic development. This feature even extends to the epigenetic reprogramming of a terminally differentiated cell nucleus as observed in connection with somatic cell nuclear transfer. Epigenetic nuclear reprogramming is highly linked to chromatin structure and includes covalent modifications of...

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PMID: 17890290
DOI: 10.1530/rep-06-0315

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