RNA-Seq transcriptome reveals different molecular responses during human and mouse oocyte maturation and fertilization

Abstract excerpt

BACKGROUND: Female infertility is a worldwide concern and the etiology of infertility has not been thoroughly demonstrated. Although the mouse is a good model system to perform functional studies, the differences between mouse and human also need to be considered. The objective of this study is to elucidate the different molecular mechanisms underlying oocyte maturation and fertilization between human and mouse....

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