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Article

MARF1 regulates essential oogenic processes in mice.

Science (New York, N.Y.) - 23 Mar 2012

Su You-Qiang, Sugiura Koji, Sun Fengyun, Pendola Janice K, Cox Gregory A, Handel Mary Ann, Schimenti John C, Eppig John J

Abstract excerpt

Development of fertilization-competent oocytes depends on integrated processes controlling meiosis, cytoplasmic development, and maintenance of genomic integrity. We show that meiosis arrest female 1 (MARF1) is required for these processes in mammalian oocytes. Mutations of Marf1 cause female infertility characterized by up-regulation of a cohort of transcripts, increased retrotransposon expression, defective...

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Source

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Identifiers

PMID: 22442484
DOI: 10.1126/science.1214680
PMCID: PMC3612990

Genes

MARF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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