Article
XRCC5 as a risk gene for alcohol dependence: evidence from a genome-wide gene-set-based analysis and follow-up studies in Drosophila and humans.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2015
Juraeva Dilafruz, Treutlein Jens, Scholz Henrike, Frank Josef, Degenhardt Franziska, Cichon Sven, Ridinger Monika, Mattheisen Manuel, Witt Stephanie H, Lang Maren, Sommer Wolfgang H, Hoffmann Per, Herms Stefan, Wodarz Norbert, Soyka Michael, Zill Peter, Maier Wolfgang, Jünger Elisabeth, Gaebel Wolfgang, Dahmen Norbert, Scherbaum Norbert, Schmäl Christine, Steffens Michael, Lucae Susanne, Ising Marcus, Smolka Michael N, Zimmermann Ulrich S, Müller-Myhsok Bertram, Nöthen Markus M, Mann Karl, Kiefer Falk, Spanagel Rainer, Brors Benedikt, Rietschel Marcella
Abstract excerpt
Genetic factors have as large role as environmental factors in the etiology of alcohol dependence (AD). Although genome-wide association studies (GWAS) enable systematic searches for loci not hitherto implicated in the etiology of AD, many true findings may be missed owing to correction for multiple testing. The aim of the present study was to circumvent this limitation by searching for biological system-level...
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