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Article

Genome-wide gene-set analysis for identification of pathways associated with alcohol dependence.

The international journal of neuropsychopharmacology - 1 Mar 2013

Biernacka Joanna M, Geske Jennifer, Jenkins Gregory D, Colby Colin, Rider David N, Karpyak Victor M, Choi Doo-Sup, Fridley Brooke L

Abstract excerpt

It is believed that multiple genetic variants with small individual effects contribute to the risk of alcohol dependence. Such polygenic effects are difficult to detect in genome-wide association studies that test for association of the phenotype with each single nucleotide polymorphism (SNP) individually. To overcome this challenge, gene-set analysis (GSA) methods that jointly test for the effects of pre-defined...

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Identifiers

PMID: 22717047
DOI: 10.1017/S1461145712000375
PMCID: PMC3854955

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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