Article
Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms.
Alcoholism, clinical and experimental research - 1 May 2017
Adkins Amy E, Hack Laura M, Bigdeli Tim B, Williamson Vernell S, McMichael G Omari, Mamdani Mohammed, Edwards Alexis C, Aliev Fazil, Chan Robin F, Bhandari Poonam, Raabe Richard C, Alaimo Joseph T, Blackwell GinaMari G, Moscati Arden, Poland Ryan S, Rood Benjamin, Patterson Diana G, Walsh Dermot, Whitfield John B, Zhu Gu, Montgomery Grant W, Henders Anjali K, Martin Nicholas G, Heath Andrew C, Madden Pamela A F, Frank Josef, Ridinger Monika, Wodarz Norbert, Soyka Michael, Zill Peter, Ising Marcus, Nöthen Markus M, Kiefer Falk, Rietschel Marcella, Gelernter Joel, Sherva Richard, Koesterer Ryan, Almasy Laura, Zhao Hongyu, Kranzler Henry R, Farrer Lindsay A, Maher Brion S, Prescott Carol A, Dick Danielle M, Bacanu Silviu A, Mathies Laura D, Davies Andrew G, Vladimirov Vladimir I, Grotewiel Mike, Bowers M Scott, Bettinger Jill C, Webb Bradley T, Miles Michael F, Kendler Kenneth S, Riley Brien P
Abstract excerpt
BACKGROUND: Alcohol dependence (AD) shows evidence for genetic liability, but genes influencing risk remain largely unidentified. METHODS: We conducted a genomewide association study in 706 related AD cases and 1,748 unscreened population controls from Ireland. We sought replication in 15,496 samples of European descent. We used model organisms (MOs) to assess the role of orthologous genes in ethanol...
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