Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variant repressing ADH1A expression confers susceptibility to esophageal squamous-cell carcinoma.

Cancer letters - 1 May 2018

Cui Qionghua, Peng Linna, Wei Lixuan, Chang Jiang, Tan Wenle, Luo Yingying, Huang Xudong, Zhao Yanjie, Li Jun, Chu Jiahui, Shao Mingming, Zhang Chao, Li Cheng, Tan Wen, Lin Dongxin, Wu Chen

Abstract excerpt

Genome-wide association studies (GWAS) have discovered numerous genetic susceptibility loci including a cluster of alcohol dehydrogenase (ADH) gene family for esophageal squamous-cell carcinoma (ESCC). However, the underlying mechanism has not fully been elucidated. In this study, we integrated the GWAS data, gene-drinking interaction, expression quantitative trait locus (eQTL) analysis and biochemical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Esophageal Neoplasms
Share to Esophageal Squamous Cell Carcinoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Genome-Wide Association Study

Share to Neurophysins

Share to Polymorphism, Single Nucleotide

Share to Protein Precursors

Share to Vasopressins

Source

Identifiers

PMID: 29248712
DOI: 10.1016/j.canlet.2017.12.020

Genes

ADH5
ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variant repressing ADH1A expression confers susceptibility to esophageal squamous-cell carcinoma.PMID 29248712Read ↗

Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk.Semantic proximity Read ↗

Alcohol Intake Interacts with Functional Genetic Polymorphisms of Aldehyde Dehydrogenase (ALDH2) and Alcohol Dehydrogenase (ADH) to Increase Esophageal Squamous Cell Cancer RiskSemantic proximity Read ↗

Single nucleotide polymorphisms of ADH1B, ADH1C and ALDH2 genes and esophageal cancer: a population-based case-control study in China.Semantic proximity Read ↗

Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles.Semantic proximity Read ↗

The ALDH7A1 genetic polymorphisms contribute to development of esophageal squamous cell carcinoma.Semantic proximity Read ↗

Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions.Semantic proximity Read ↗

Replication study of ESCC susceptibility genetic polymorphisms locating in the ADH1B-ADH1C-ADH7 cluster identified by GWAS.Semantic proximity Read ↗

Association between ADH1B and ADH1C polymorphisms and the risk of head and neck squamous cell carcinoma.Semantic proximity Read ↗

Relationship between esophageal squamous cell carcinoma risk and alcohol-related ALDH2 and ADH1B polymorphisms: Evidence from a meta-analysis and Mendelian randomization analysis.Semantic proximity Read ↗

Tag single nucleotide polymorphisms of alcohol-metabolizing enzymes modify the risk of upper aerodigestive tract cancers: HapMap database analysis.Semantic proximity Read ↗

Genes encoding enzymes involved in ethanol metabolismSemantic proximity Read ↗

ADH7 Polymorphism and Alcohol Consumption on Risk of Head and Neck Squamous Cell Carcinoma in The Korean PopulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.