Article
Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster.
Genome biology - 1 Jan 2007
Morozova Tatiana V, Anholt Robert R H, Mackay Trudy F C
Abstract excerpt
BACKGROUND: Alcoholism is a complex disorder determined by interactions between genetic and environmental risk factors. Drosophila represents a powerful model system to dissect the genetic architecture of alcohol sensitivity, as large numbers of flies can readily be reared in defined genetic backgrounds and under controlled environmental conditions. Furthermore, flies exposed to ethanol undergo physiological and...
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