Article
Significance of the coexistence of non-codon 315 katG, inhA, and oxyR-ahpC intergenic gene mutations among isoniazid-resistant and multidrug-resistant isolates of Mycobacterium tuberculosis: a report of novel mutations.
Pathogens and global health - 1 Feb 2022
Norouzi Fatemeh, Moghim Sharareh, Farzaneh ShimaSadat, Fazeli Hossein, Salehi Mahshid, Nasr Esfahani Bahram
Abstract excerpt
Tuberculosis (TB) is a global threat due to the emergence and spread of drug-resistant Mycobacterium tuberculosis (MTB). Isoniazid (INH) is the main antibiotic used for prevention and treatment of TB. Evidence shows that accumulated mutations can produce INH resistant (INHR) strains, resulting in the progression of multidrug-resistant (MDR) TB. Since point mutations in katG gene, inhA gene, and oxyR-ahpC region...
Topics
- Antitubercular Agents
- Bacterial Proteins
- DNA, Bacterial
- DNA, Intergenic
- Humans
- Isoniazid
- Microbial Sensitivity Tests
- Mutation
- Mycobacterium tuberculosis
- Tuberculosis