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Whole genome sequencing of isoniazid monoresistant clinical isolates of Mycobacterium tuberculosis reveals novel genetic polymorphisms.

Tuberculosis (Edinburgh, Scotland) - 1 Mar 2022

Gupta Shraddha, Kumar Chanchal, Shrivastava Kamal, Chauhan Varsha, Singh Anupriya, Arora Rohan, Giri Astha, Cabibbe Andrea Maurizio, Sharma Naresh Kumar, Spitaleri Andrea, Cirillo Daniela Maria, Bose Mridula, Varma-Basil Mandira

Abstract excerpt

In an attempt to uncover genotypic indicators for isoniazid (INH) resistance in M. tuberculosis, in addition to the canonical mutations in genes associated with INH resistance, including katG, inhA and fabG promoter; we analyzed, two INH monoresistant isolates, ASTS24/13 (INHR1) and SHR1/14 (INHR2). Targeted Sanger sequencing detected a canonical mutation at katG315 only in INHR2. Infection of THP-1 cells and...

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PMID: 35158296
DOI: 10.1016/j.tube.2022.102173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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