Article
Protein mistranslation: friend or foe?
Trends in biochemical sciences - 1 Aug 2014
Ribas de Pouplana Liuís, Santos Manuel A S, Zhu Jun-Hao, Farabaugh Philip J, Javid Babak
Abstract excerpt
The translation of genes into functional proteins involves error. Mistranslation is a known cause of disease, but, surprisingly, recent studies suggest that certain organisms from all domains of life have evolved diverse pathways that increase their tolerance of translational error. Although the reason for these high error rates are not yet clear, evidence suggests that increased mistranslation may have a role in...
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