Article

Proteome-wide identification of amino acid substitutions deleterious for protein function

2022-04-09

Abstract excerpt

DNA sequencing has led to the discovery of millions of mutations that change the encoded protein sequences, but the impact of nearly all of these mutations on protein function is unknown. We addressed this scarcity of functional data by developing Miro, a proteomic technology that uses mistranslation to introduce amino acid substitutions and biochemical assays to quantify functional differences of thousands of pro...

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Literature Corpus work: d270f846-ca96-55c2-8e16-9c9d8f7f6639
DOI: 10.1101/2022.04.06.487405

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