Article
Protein mistranslation protects bacteria against oxidative stress.
Nucleic acids research - 18 Feb 2015
Fan Yongqiang, Wu Jiang, Ung Matthew H, De Lay Nicholas, Cheng Chao, Ling Jiqiang
Abstract excerpt
Accurate flow of genetic information from DNA to protein requires faithful translation. An increased level of translational errors (mistranslation) has therefore been widely considered harmful to cells. Here we demonstrate that surprisingly, moderate levels of mistranslation indeed increase tolerance to oxidative stress in Escherichia coli. Our RNA sequencing analyses revealed that two antioxidant genes katE and...
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