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Article

Comprehensive analysis of UGT1A1 polymorphisms through high-resolution melting analysis and DNA sequencing.

Clinical laboratory - 1 Jan 2014

Tsai Shin-Yi, Er Tze-Kiong, Lin Chin-Wen, Chang Jan-Gowth

Abstract excerpt

BACKGROUND: Uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) is a key conjugating enzyme of bilirubin and the anti-tumor medication irinotecan. Comprehensive analysis of UGT1A1 gene polymorphisms may provide benefit by predicting pharmacokinetics and outcomes of treatment with irinotecan and certain antiviral medications. METHODS: A high-resolution melting (HRM) analysis was designed to characterize the...

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PMID: 25016708
DOI: 10.7754/clin.lab.2013.130707

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