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Article

Rapid detection of the irinotecan-related UGT1A1 & 5-fluorouracil related DPYD polymorphism by asymmetric polymerase chain reaction melting curve analysis.

Clinica chimica acta; international journal of clinical chemistry - 15 Jul 2024

Lian Jiabian, Liang Yaoji, Wang Yunling, Chen Ying, Li Xun, Xia Lu

Abstract excerpt

BACKGROUND: Determination of DPYD and UGT1A1 polymorphisms prior to 5-fluorouracil and irinotecan therapy is crucial for avoiding severe adverse drug effects. Hence, there is a pressing need for accurate and reliable genotyping methods for the most common DPYD and UGT1A1 polymorphisms. In this study, we introduce a novel polymerase chain reaction (PCR) melting curve analysis method for discriminating DPYD...

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Share to Dihydrouracil Dehydrogenase (NADP)
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38848897
DOI: 10.1016/j.cca.2024.119761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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