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Article

Analytical validation of a high-resolution melting assay for UGT1A1 TATA-box polymorphisms.

Molecular biology reports - 8 Jul 2026

Gambarino Stefano, Clemente Anna, Pau Anna, Calvi Cristina, Montanari Paola, Galliano Ilaria, Bergallo Massimiliano

Abstract excerpt

BACKGROUND: Polymorphisms in the TATA-box of the UGT1A1 promoter are responsible for Gilbert syndrome and play a key role in irinotecan-related toxicity. Reliable, rapid, and cost-effective genotyping methods are therefore required in routine molecular diagnostics. METHODS AND RESULTS: We performed an analytical validation of a High-Resolution Melting (HRM) assay designed to discriminate UGT1A1 TATA-box alleles....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42417882
DOI: 10.1007/s11033-026-12240-9
PMCID: PMC13346157

Genes

UGT1A1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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