Rapid UGT1A1 (TA)(n) genotyping by high resolution melting curve analysis for Gilbert's syndrome diagnosis.

doi:10.1016/j.cca.2009.11.013

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Article

Rapid UGT1A1 (TA)(n) genotyping by high resolution melting curve analysis for Gilbert's syndrome diagnosis.

Clinica chimica acta; international journal of clinical chemistry - 1 Feb 2010

Minucci Angelo, Concolino Paola, Giardina Bruno, Zuppi Cecilia, Capoluongo Ettore

Abstract excerpt

BACKGROUND: The basis of Gilbert's syndrome is a 70% reduction in bilirubin glucuronidation which, in the Caucasian population, is the result of a homozygous TA insertion into the promoter region of the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene (UGT1A128 allele). In addition, homozygous subjects for UGT1A128 genotype may suffer from severe irinotecan toxicity or jaundice during treatment with the protease...

Topics

Genotype
Gilbert Disease
Glucuronosyltransferase
Humans
Nucleic Acid Denaturation
TATA Box
Time Factors
Transition Temperature

Source

Open in PubMed

Identifiers

PMID: 19932091
DOI: 10.1016/j.cca.2009.11.013

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