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Article

Rapid UGT1A1 (TA)(n) genotyping by high resolution melting curve analysis for Gilbert's syndrome diagnosis.

Clinica chimica acta; international journal of clinical chemistry - 1 Feb 2010

Minucci Angelo, Concolino Paola, Giardina Bruno, Zuppi Cecilia, Capoluongo Ettore

Abstract excerpt

BACKGROUND: The basis of Gilbert's syndrome is a 70% reduction in bilirubin glucuronidation which, in the Caucasian population, is the result of a homozygous TA insertion into the promoter region of the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene (UGT1A128 allele). In addition, homozygous subjects for UGT1A128 genotype may suffer from severe irinotecan toxicity or jaundice during treatment with the protease...

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Identifiers

PMID: 19932091
DOI: 10.1016/j.cca.2009.11.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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