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Localization of APOL1 Protein and mRNA in the Human Kidney

10 Jul 2014

Abstract excerpt

Although APOL1 gene variants are associated with nephropathy in African Americans, little is known about APOL1 protein synthesis, uptake, and localization in kidney cells. To address these questions, we examined APOL1 protein and mRNA localization in human kidney and human kidney-derived cell lines. Indirect immunofluorescence microscopy performed on nondiseased nephrectomy cryosections from persons with normal...

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PMID: 25012173
DOI: 10.1681/asn.2013091017

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