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Article

Mechanisms of Injury in APOL1-associated Kidney Disease

29 Oct 2018

Abstract excerpt

BACKGROUND: An improved understanding of the pathogenesis in apolipoprotein L1 (APOL1) gene-associated chronic kidney disease (CKD) arose from observations in kidney transplantation. APOL1 genotyping could soon improve the safety of living kidney donation in individuals with recent African ancestry and alter the allocation of deceased donor kidneys. METHODS: This article reviews the potential mechanisms that...

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PMID: 30371607
DOI: 10.1097/tp.0000000000002509

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