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Transcriptomic Analysis of Human Podocytes In Vitro: Effects of Differentiation and APOL1 Genotype

17 Oct 2022

Abstract excerpt

Introduction The mechanisms in podocytes that mediate the pathologic effects of the APOL1 high-risk (HR) variants remain incompletely understood, although various molecular and cellular mechanisms have been proposed. We previously established conditionally immortalized human urine-derived podocyte-like epithelial cell (HUPEC) lines to investigate APOL1 HR variant–induced podocytopathy. Methods We conducted...

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PMID: 36644347
DOI: 10.1016/j.ekir.2022.10.011

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