Article
APOL1 localization in normal kidney and nondiabetic kidney disease.
Journal of the American Society of Nephrology : JASN - 1 Nov 2011
Madhavan Sethu M, O'Toole John F, Konieczkowski Martha, Ganesan Santhi, Bruggeman Leslie A, Sedor John R
Abstract excerpt
In patients of African ancestry, genetic variants in APOL1, which encodes apolipoprotein L1, associate with the nondiabetic kidney diseases, focal segmental glomerulosclerosis (FSGS), HIV-associated nephropathy (HIVAN), and hypertensive nephropathy. Understanding the renal localization of APOL1 may provide clues that will ultimately help elucidate the mechanisms by which APOL1 variants promote nephropathy. Here,...
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