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Article

APOL1 and kidney cell function

26 Jun 2019

Abstract excerpt

The apolipoprotein L1 (APOL1) gene is unique to humans and gorillas and appeared ~33 million years ago. Since the majority of the mammals do not carry APOL1, it seems to be dispensable for kidney function. APOL1 renal risk variants (RRVs; G1 and G2) are associated with the development as well as progression of chronic kidney diseases (CKDs) at higher rates in populations with African ancestry. Cellular expression...

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PMID: 31241995
DOI: 10.1152/ajprenal.00233.2019

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