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APOL1 renal risk variants exacerbate podocyte injury by increasing inflammatory stress

27 Aug 2020

Abstract excerpt

BACKGROUND: Apolipoprotein L1, APOL1, is a trypanosome lytic factor present in human and certain other primates. APOL1 gene variants, present in individuals of recent sub-Saharan African descent, increase risk for glomerular disease and associate with the disease progression, but the molecular mechanisms have not been defined. OBJECTIVES: We focus on the mechanism how APOL1 variant proteins enhance podocyte...

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PMID: 32854642
DOI: 10.1186/s12882-020-01995-3

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