Article
Lack of APOL1 in proximal tubules of normal human kidneys and proteinuric APOL1 transgenic mouse kidneys.
PloS one - 1 Jan 2021
Blessing Natalya A, Wu Zhenzhen, Madhavan Sethu M, Choy Jonathan W, Chen Michelle, Shin Myung K, Hoek Maarten, Sedor John R, O'Toole John F, Bruggeman Leslie A
Abstract excerpt
The mechanism of pathogenesis associated with APOL1 polymorphisms and risk for non-diabetic chronic kidney disease (CKD) is not fully understood. Prior studies have minimized a causal role for the circulating APOL1 protein, thus efforts to understand kidney pathogenesis have focused on APOL1 expressed in renal cells. Of the kidney cells reported to express APOL1, the proximal tubule expression patterns are...
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