Article
Nonpodocyte Roles of APOL1 Variants: An Evolving Paradigm.
Kidney360 - 1 Sept 2023
Pell John, Nagata Soichiro, Menon Madhav C
Abstract excerpt
Since the seminal discovery of the trypanolytic, exonic variants in apolipoprotein L1 (APOL1) and their association with kidney disease in individuals of recent African ancestry, a wide body of research has emerged offering key insights into the mechanisms of disease. Importantly, the podocyte has become a focal point for our understanding of how risk genotype leads to disease, with activation of putative...
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