Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exon 4-encoded sequence is a major determinant of cytotoxicity of apolipoprotein L1

30 Apr 2015

Abstract excerpt

The apolipoprotein L1 (APOL1) gene (APOL1) product is toxic to kidney cells, and its G1 and G2 alleles are strongly associated with increased risk for kidney disease progression in African Americans. Variable penetrance of the G1 and G2 risk alleles highlights the significance of additional factors that trigger or modify the progression of disease. In this regard, the effect of alternative splicing in the absence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Lymphocytic Leukemia Research
Share to PI3K/AKT/mTOR signaling in cancer
Share to Renal Diseases and Glomerulopathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25924622
DOI: 10.1152/ajpcell.00384.2014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exon 4-encoded sequence is a major determinant of cytotoxicity of apolipoprotein L1PMID 25924622Read ↗

Recruitment of APOL1 kidney disease risk variants to lipid droplets attenuates cell toxicitySemantic proximity Read ↗

ApoL1 Overexpression Drives Variant-Independent Cytotoxicity.Semantic proximity Read ↗

Biogenesis and cytotoxicity of APOL1 renal risk variant proteins in hepatocytes and hepatoma cells.Semantic proximity Read ↗

APOL1-associated kidney disease: modulators of the genotype-phenotype relationship.Semantic proximity Read ↗

APOL1-mediated monovalent cation transport contributes to APOL1-mediated podocytopathy in kidney disease.Semantic proximity Read ↗

APOL1 Kidney Risk Variants Induce Cell Death via Mitochondrial Translocation and Opening of the Mitochondrial Permeability Transition Pore.Semantic proximity Read ↗

APOL1 and kidney cell functionSemantic proximity Read ↗

Kidney Disease-Associated APOL1 Variants Have Dose-Dependent, Dominant Toxic Gain-of-Function.Semantic proximity Read ↗

Genomewide Screen Identifies Peroxisomal Role in APOL1 PodocytopathySemantic proximity Read ↗

APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases.Semantic proximity Read ↗

Apolipoprotein L1 (APOL1) renal risk variant-mediated podocyte cytotoxicity depends on African haplotype and surface expression.Semantic proximity Read ↗

APOL1 polymorphisms and kidney disease: loss-of-function or gain-of-function?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.