Article
Chromosome-breakage genomic instability and chromothripsis in breast cancer.
BMC genomics - 9 Jul 2014
Przybytkowski Ewa, Lenkiewicz Elizabeth, Barrett Michael T, Klein Kathleen, Nabavi Sheida, Greenwood Celia M T, Basik Mark
Abstract excerpt
BACKGROUND: Chromosomal breakage followed by faulty DNA repair leads to gene amplifications and deletions in cancers. However, the mere assessment of the extent of genomic changes, amplifications and deletions may reduce the complexity of genomic data observed by array comparative genomic hybridization (array CGH). We present here a novel approach to array CGH data analysis, which focuses on putative breakpoints...
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