Article
Chromothripsis: chromosomes in crisis.
Developmental cell - 13 Nov 2012
Jones Mathew J K, Jallepalli Prasad V
Abstract excerpt
During oncogenesis, cells acquire multiple genetic alterations that confer essential tumor-specific traits, including immortalization, escape from antimitogenic signaling, neovascularization, invasiveness, and metastatic potential. In most instances, these alterations are thought to arise incrementally over years, if not decades. However, recent progress in sequencing cancer genomes has begun to challenge this...
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