Chromothripsis in acute myeloid leukemia: biological features and impact on survival.

doi:10.1038/s41375-018-0035-y

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Chromothripsis in acute myeloid leukemia: biological features and impact on survival.

Leukemia - 1 Jul 2018

Fontana Maria Chiara, Marconi Giovanni, Feenstra Jelena D Milosevic, Fonzi Eugenio, Papayannidis Cristina, Ghelli Luserna di Rorá Andrea, Padella Antonella, Solli Vincenza, Franchini Eugenia, Ottaviani Emanuela, Ferrari Anna, Baldazzi Carmen, Testoni Nicoletta, Iacobucci Ilaria, Soverini Simona, Haferlach Torsten, Guadagnuolo Viviana, Semerad Lukas, Doubek Michael, Steurer Michael, Racil Zdenek, Paolini Stefania, Manfrini Marco, Cavo Michele, Simonetti Giorgia, Kralovics Robert, Martinelli Giovanni

Abstract excerpt

Chromothripsis is a one-step genome-shattering catastrophe resulting from disruption of one or few chromosomes in multiple fragments and consequent random rejoining and repair. This study defines incidence of chromothripsis in 395 newly diagnosed adult acute myeloid leukemia (AML) patients from three institutions, its impact on survival and its genomic background. SNP 6.0 or CytoscanHD Array (Affymetrix®) were...

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PMID: 29472722
DOI: 10.1038/s41375-018-0035-y
PMCID: PMC6035145

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FLT3
NPM1

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