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Chromothripsis in Chronic Lymphocytic Leukemia: A Driving Force of Genome Instability

26 Nov 2021

Abstract excerpt

Chromothripsis represents a mechanism of massive chromosome shattering and reassembly leading to the formation of derivative chromosomes with abnormal functions and expression. It has been observed in many cancer types, importantly, including chronic lymphocytic leukemia (CLL). Due to the associated chromosomal rearrangements, it has a significant impact on the pathophysiology of the disease. Recent studies have...

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PMID: 34900721
DOI: 10.3389/fonc.2021.771664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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