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Article

Identification of Chromothripsis in Biopsy Using SNP-Based Microarray.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Ortega Veronica, Mendiola Christina, Velagaleti Gopalrao V N

Abstract excerpt

One of the well-known hallmarks of cancer is genomic instability. Although gradualism is a well-established process of cancer evolution, recent studies have shown that chromothripsis or chromoanasynthesis can result in complex genomic rearrangements by a single catastrophic event rather than several incremental steps. These two novel phenomena suggest an evolutionary modality for cancer cells to circumvent...

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PMID: 29564820
DOI: 10.1007/978-1-4939-7780-2_7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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