Article
Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus.
PloS one - 1 Jan 2014
Garner Chad, Ahn Richard, Ding Yuan Chun, Steele Linda, Stoven Samantha, Green Peter H, Fasano Alessio, Murray Joseph A, Neuhausen Susan L
Abstract excerpt
We performed a genome-wide association study (GWAS) of 1550 North American celiac disease cases and 3084 controls. Twelve SNPs, distributed across four regions (3p21.31, 4q27, 6q15, 6q25), were significantly associated with disease (p-value <1.0×10-7), and a further seven SNPs, across four additional regions (1q24.3, 10p15.1, 6q22.31, 17q21.32) had suggestive evidence (1.0×10-7 < p-value < 1.0×10-6). This study...
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