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Article

Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations.

Tissue antigens - 1 Nov 2009

Koskinen L L E, Einarsdottir E, Korponay-Szabo I R, Kurppa K, Kaukinen K, Sistonen P, Pocsai Z, Széles G, Adány R, Mäki M, Kere J, Saavalainen P

Abstract excerpt

Celiac disease is a chronic inflammation of the small intestine, arising in genetically predisposed individuals as a result of ingestion of dietary gluten. The only confirmed and functionally characterised genetic risk factors for celiac disease are the DQ2 or DQ8 heterodimers at the major histocompatibility complex (MHC) class II locus (CELIAC1). These genes are necessary but alone not sufficient for disease...

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PMID: 19845895
DOI: 10.1111/j.1399-0039.2009.01359.x

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