Genome-wide association study identifies novel risk variants for celiac disease in the 5p15.33 locus: insights from a population-based screening of adults, the HUNT study

Abstract excerpt

Previous studies have uncovered genetic loci associated with celiac disease (CeD) within both the human leukocyte antigen (HLA) and non-HLA regions. However, half of the heritability remains unexplained. This study aimed to identify novel loci associated with CeD in a general adult population screened for the disease, mitigating the likely selection bias observed in previous case-control studies. The study utilize...

Topics

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• Case-Control Studies
• Celiac Disease
• Gene Frequency
• Gene Regulatory Networks
• Genetic Loci
• Genome, Human
• Genomics
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

a053d23c-50ce-5a71-ab63-69220727744d

DOI

10.1101/2024.12.09.24318711